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Lab-on-CMOS — an in-vitro diagnostic (IVD) tool for a healthier society

Pui-In Mak

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Abstract: Towards a sustainable healthcare system, the clinical-grade diagnostic platform should be decentralized into low-cost consumer-grade handheld devices, for broadly and early disease screening and diagnosis. The joint advancement of CMOS biosensors and signal-processing capability has recently transformed bulky laboratory instruments into handheld devices, leading to cost, size and weight reduction by orders of magnitude. This article gives a glimpse of the lab-on-CMOS in-vitro diagnostic (IVD) tools for point-of-care applications.



Fig. 1.  (Color online) A handheld NMR CMOS platform: (left) chip photo and its applications for multi-type assays, and (right) platform assembly. Courtesy K.M. Lei ISSCC 2016.

Fig. 2.  (Color online) System block diagram of the NMR transceiver. The transmitter and receiver transduce between magnetic and electrical signals with a thermal-controlled spiral coil. The B0-field sensor and calibrator automatically stabilize the bulk magnetization on the μL-sample. Courtesy K.M. Lei ISSCC 2016.

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    Received: Revised: Online: Uncorrected proof: 23 October 2020Published: 03 November 2020

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      Pui-In Mak. Lab-on-CMOS — an in-vitro diagnostic (IVD) tool for a healthier society[J]. Journal of Semiconductors, 2020, 41(11): 110301. doi: 10.1088/1674-4926/41/11/110301 P I Mak, Lab-on-CMOS — an in-vitro diagnostic (IVD) tool for a healthier society[J]. J. Semicond., 2020, 41(11): 110301. doi: 10.1088/1674-4926/41/11/110301.Export: BibTex EndNote
      Citation:
      Pui-In Mak. Lab-on-CMOS — an in-vitro diagnostic (IVD) tool for a healthier society[J]. Journal of Semiconductors, 2020, 41(11): 110301. doi: 10.1088/1674-4926/41/11/110301

      P I Mak, Lab-on-CMOS — an in-vitro diagnostic (IVD) tool for a healthier society[J]. J. Semicond., 2020, 41(11): 110301. doi: 10.1088/1674-4926/41/11/110301.
      Export: BibTex EndNote

      Lab-on-CMOS — an in-vitro diagnostic (IVD) tool for a healthier society

      doi: 10.1088/1674-4926/41/11/110301
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      • Author Bio:

        Pui-In Mak Pui-In Mak (Elvis) is the Professor of the State-Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, China. His research interests are on analog and radio-frequency (RF) circuits and systems for wireless and multidisciplinary innovations. Prof. Mak is the Overseas Expert of the Chinese Academy of Sciences, and Fellow of the IEEE, IET and United Kingdom Royal Society of Chemistry (RSC)

      • Published Date: 2020-11-10

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