A wearable sweat patch for non-invasive and wireless monitoring inflammatory status

Qilin Hua; Guozhen Shen

doi:10.1088/1674-4926/44/10/100401

J. Semicond. > 2023, Volume 44 > Issue 10 > 100401, doi: 10.1088/1674-4926/44/10/100401

NEWS AND VIEWS

A wearable sweat patch for non-invasive and wireless monitoring inflammatory status

Qilin Hua and Guozhen Shen

+ Author Affiliations

Corresponding author: Guozhen Shen, gzshen@bit.edu.cn

References

[1]	Bariya M, Nyein H Y Y, Javey A. Wearable sweat sensors. Nat Electron, 2018, 1, 160 doi: 10.1038/s41928-018-0043-y
[2]	Heikenfeld J. Bioanalytical devices: Technological leap for sweat sensing. Nature, 2016, 529, 475 doi: 10.1038/529475a
[3]	Shi Y Q, Zhang Z Y, Huang Q Y, et al. Wearable sweat biosensors on textiles for health monitoring. J Semicond, 2023, 44, 021601 doi: 10.1088/1674-4926/44/2/021601
[4]	Ye Y, Wang H, Tian Y, et al. Smart epidermal electrophysiological electrodes: Materials, structures, and algorithms. Nanotechnology and Precision Engineering (NPE), 2023, 6, 045001. doi: doi.org/10.1063/10.0019678
[5]	Wu F M, Liu Y X, Zhang J, et al. Highly stretchable and high-mobility simiconducting nanofibrous blend films for fully stretchable organic transistors. Sci China Mater, 2023, 66, 1891 doi: 10.1007/s40843-022-2331-8
[6]	Liu B, Chen X, Cai H L, et al. Surface acoustic wave devices for sensor applications. J Semicond, 2016, 37, 021001 doi: 10.1088/1674-4926/37/2/021001
[7]	Zhang T Y, Yao G, Pan T S, et al. Flexible inorganic oxide thin-film electronics enabled by advanced strategies. J Semicond, 2020, 41, 041602 doi: 10.1088/1674-4926/41/4/041602
[8]	Lu Y, Jiang K, Chen D, et al. Wearable sweat monitoring system with integrated micro-supercapacitors. Nano Energy, 2019, 58, 624 doi: 10.1016/j.nanoen.2019.01.084
[9]	Bandodkar A J, Jia W Z, Yardımcı C, et al. Tattoo-based noninvasive glucose monitoring: A proof-of-concept study. Anal Chem, 2015, 87, 394 doi: 10.1021/ac504300n
[10]	Gao W, Emaminejad S, Nyein H Y Y, et al. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature, 2016, 529, 509 doi: 10.1038/nature16521
[11]	Ferrucci L, Fabbri E. Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol, 2018, 15, 505 doi: 10.1038/s41569-018-0064-2
[12]	Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med, 2019, 25, 1822 doi: 10.1038/s41591-019-0675-0
[13]	Pepys M B, Hirschfield G M. C-reactive protein: A critical update. J Clin Invest, 2003, 111, 1805 doi: 10.1172/JCI200318921
[14]	Tu J B, Min J H, Song Y, et al. A wireless patch for the monitoring of C-reactive protein in sweat. Nat Biomed Eng, 2023 June, PMID: 37349389 doi: 10.1038/s41551-023-01059-5

Fig. 1. (Color online) A wearable electrochemical biosensor patch for wireless monitoring CRP from sweat^[14]. (a) Circulating CRP obtained from the sweat gland could reflect inflammatory responses to chronic and acute health conditions. (b) Schematic illustration of the skin-interfaced wearable biosensor with multiple modules, including iontophoresis, microfluidics, LEG-based multimodal sensor arrays, and FPCB. (c) Optical image of the disposable microfluidic component. (d) Optical image of the vertically stacked sweat sensor patch. (Scale bars: 0.5 cm). (e) The working principle of the sensor patch for in-situ sweat CRP analysis. (f) Schematic illustrating non-invasive inflammation monitoring in various health conditions using the sensor patch. (g) Box-and-whisker plot of CRP analysis for iontophoresis-extracted sweat and serum samples from COPD and non-COPD patients.

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[1]	Bariya M, Nyein H Y Y, Javey A. Wearable sweat sensors. Nat Electron, 2018, 1, 160 doi: 10.1038/s41928-018-0043-y
[2]	Heikenfeld J. Bioanalytical devices: Technological leap for sweat sensing. Nature, 2016, 529, 475 doi: 10.1038/529475a
[3]	Shi Y Q, Zhang Z Y, Huang Q Y, et al. Wearable sweat biosensors on textiles for health monitoring. J Semicond, 2023, 44, 021601 doi: 10.1088/1674-4926/44/2/021601
[4]	Ye Y, Wang H, Tian Y, et al. Smart epidermal electrophysiological electrodes: Materials, structures, and algorithms. Nanotechnology and Precision Engineering (NPE), 2023, 6, 045001. doi: doi.org/10.1063/10.0019678
[5]	Wu F M, Liu Y X, Zhang J, et al. Highly stretchable and high-mobility simiconducting nanofibrous blend films for fully stretchable organic transistors. Sci China Mater, 2023, 66, 1891 doi: 10.1007/s40843-022-2331-8
[6]	Liu B, Chen X, Cai H L, et al. Surface acoustic wave devices for sensor applications. J Semicond, 2016, 37, 021001 doi: 10.1088/1674-4926/37/2/021001
[7]	Zhang T Y, Yao G, Pan T S, et al. Flexible inorganic oxide thin-film electronics enabled by advanced strategies. J Semicond, 2020, 41, 041602 doi: 10.1088/1674-4926/41/4/041602
[8]	Lu Y, Jiang K, Chen D, et al. Wearable sweat monitoring system with integrated micro-supercapacitors. Nano Energy, 2019, 58, 624 doi: 10.1016/j.nanoen.2019.01.084
[9]	Bandodkar A J, Jia W Z, Yardımcı C, et al. Tattoo-based noninvasive glucose monitoring: A proof-of-concept study. Anal Chem, 2015, 87, 394 doi: 10.1021/ac504300n
[10]	Gao W, Emaminejad S, Nyein H Y Y, et al. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature, 2016, 529, 509 doi: 10.1038/nature16521
[11]	Ferrucci L, Fabbri E. Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol, 2018, 15, 505 doi: 10.1038/s41569-018-0064-2
[12]	Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med, 2019, 25, 1822 doi: 10.1038/s41591-019-0675-0
[13]	Pepys M B, Hirschfield G M. C-reactive protein: A critical update. J Clin Invest, 2003, 111, 1805 doi: 10.1172/JCI200318921
[14]	Tu J B, Min J H, Song Y, et al. A wireless patch for the monitoring of C-reactive protein in sweat. Nat Biomed Eng, 2023 June, PMID: 37349389 doi: 10.1038/s41551-023-01059-5