SEMICONDUCTOR INTEGRATED CIRCUITS
Abstract: A CMOS fluorescent detector system for biological experiment is presented. This system integrates a CMOS compatible photodiode, a capacitive trans-impedance amplifier (CTIA), and a 12 bit pipelined analog-to-digital converter (ADC), and is implemented in a 0.18 mm standard CMOS process. Some special techniques, such as a “contact imaging” detecting method, pseudo-differential architecture, dummy photodiodes, and a T-type reset switch, are adopted to achieve low-level sensing application. Experiment results show that the Nwell/Psub photodiode with CTIA pixel achieves a sensitivity of 0.1 A/W at 515 nm and a dark current of 300 fA with 300 mV reverse biased voltage. The maximum differential and integral nonlinearity of the designed ADC are 0.8 LSB and 3 LSB, respectively. With an integrating time of 50 ms, this system is sensitive to the fluorescence emitted by the fluorescein solution with concentration as low as 20 ng/mL and can generate 7 fA photocurrent. This chip occupies 3 mm2 and consumes 37 mW.
Key words: fluorescence detecting, contact imaging, pipelined ADC, CTIA pixel
| 1 |
A 10 b 50 MS/s two-stage pipelined SAR ADC in 180 nm CMOS Yi Shen, Shubin Liu, Zhangming Zhu Journal of Semiconductors, 2016, 37(6): 065001. doi: 10.1088/1674-4926/37/6/065001 |
| 2 |
A SHA-less 14-bit, 100-MS/s pipelined ADC with comparator offset cancellation in background Xiaofei Wang, Hong Zhang, Jie Zhang, Xin Du, Yue Hao, et al. Journal of Semiconductors, 2016, 37(3): 035002. doi: 10.1088/1674-4926/37/3/035002 |
| 3 |
High performance 14-bit pipelined redundant signed digit ADC Swina Narula, Sujata Pandey Journal of Semiconductors, 2016, 37(3): 035001. doi: 10.1088/1674-4926/37/3/035001 |
| 4 |
A 430 mW 16 b 170 MS/s CMOS pipelined ADC with 77.2 dB SNR and 97.6 dB SFDR Hui Zhang, Dan Li, Lei Wan, Hui Zhang, Haijun Wang, et al. Journal of Semiconductors, 2016, 37(3): 035003. doi: 10.1088/1674-4926/37/3/035003 |
| 5 |
Packaging investigation of optoelectronic devices Zhike Zhang, Yu Liu, Jianguo Liu, Ninghua Zhu Journal of Semiconductors, 2015, 36(10): 101001. doi: 10.1088/1674-4926/36/10/101001 |
| 6 |
A 14-bit 100-MS/s CMOS pipelined ADC featuring 83.5-dB SFDR Nan Zhao, Qi Wei, Huazhong Yang, Hui Wang Journal of Semiconductors, 2014, 35(9): 095009. doi: 10.1088/1674-4926/35/9/095009 |
| 7 |
A 14-bit 100-MS/s CMOS pipelined ADC with 11.3 ENOB Ke Wang, Chaojie Fan, Jianjun Zhou, Wenjie Pan Journal of Semiconductors, 2013, 34(8): 085015. doi: 10.1088/1674-4926/34/8/085015 |
| 8 |
SHA-less architecture with enhanced accuracy for pipelined ADC Zhao Lei, Yang Yintang, Zhu Zhangming, Liu Lianxi Journal of Semiconductors, 2012, 33(2): 025010. doi: 10.1088/1674-4926/33/2/025010 |
| 9 |
A 12-bit, 40-Ms/s pipelined ADC with an improved operational amplifier Wang Yu, Yang Haigang, Yin Tao, Liu Fei Journal of Semiconductors, 2012, 33(5): 055004. doi: 10.1088/1674-4926/33/5/055004 |
| 10 |
A robust and simple two-mode digital calibration technique for pipelined ADC Yin Xiumei, Zhao Nan, Sekedi Bomeh Kobenge, Yang Huazhong Journal of Semiconductors, 2011, 32(3): 035001. doi: 10.1088/1674-4926/32/3/035001 |
| 11 |
A 10-bit 80-MS/s opamp-sharing pipelined ADC with a switch-embedded dual-input MDAC Yin Rui, Liao Youchun, Zhang Wei, Tang Zhangwen Journal of Semiconductors, 2011, 32(2): 025006. doi: 10.1088/1674-4926/32/2/025006 |
| 12 |
An 8-bit 100-MS/s pipelined ADC without dedicated sample-and-hold amplifier Zhang Zhang, Yuan Yudan, Guo Yawei, Cheng Xu, Zeng Xiaoyang, et al. Journal of Semiconductors, 2010, 31(7): 075006. doi: 10.1088/1674-4926/31/7/075006 |
| 13 |
A 10-bit 50-MS/s subsampling pipelined ADC based on SMDAC and opamp sharing Chen Lijie, Zhou Yumei, Wei Baoyue Journal of Semiconductors, 2010, 31(11): 115006. doi: 10.1088/1674-4926/31/11/115006 |
| 14 |
A 1.2-V 19.2-mW 10-bit 30-MS/s pipelined ADC in 0.13-μm CMOS Zhang Zhang, Yuan Yudan, Guo Yawei, Cheng Xu, Zeng Xiaoyang, et al. Journal of Semiconductors, 2010, 31(9): 095014. doi: 10.1088/1674-4926/31/9/095014 |
| 15 |
A 12 bit 100 MS/s pipelined analog to digital converter without calibration Cai Xiaobo, Li Fule, Zhang Chun, Wang Zhihua Journal of Semiconductors, 2010, 31(11): 115007. doi: 10.1088/1674-4926/31/11/115007 |
| 16 |
Geng Fei, Ding Xiaoyun, Xu Gaowei, Luo Le Journal of Semiconductors, 2009, 30(10): 106003. doi: 10.1088/1674-4926/30/10/106003 |
| 17 |
Wafer level hermetic packaging based on Cu–Sn isothermal solidification technology Cao Yuhan, Luo Le Journal of Semiconductors, 2009, 30(8): 086001. doi: 10.1088/1674-4926/30/8/086001 |
| 18 |
A novel low-voltage operational amplifier for low-power pipelined ADCs Fan Mingjun, Ren Junyan, Guo Yao, Li Ning, Ye Fan, et al. Journal of Semiconductors, 2009, 30(1): 015009. doi: 10.1088/1674-4926/30/1/015009 |
| 19 |
A 10bit 50MS/s Pipeline ADC Design for a Million Pixels Level CMOS Image Sensor Zhu Tiancheng, Yao Suying, Yuan Xiaoxing, Li Binqiao Journal of Semiconductors, 2008, 29(10): 1939-1946. |
| 20 |
A CMOS Dynamic Comparator for Pipelined ADCs with Improved Speed/Power Ratio Liu Ke, Yang Haigang Journal of Semiconductors, 2008, 29(1): 75-81. |
Article views: 3651 Times PDF downloads: 2452 Times Cited by: 0 Times
Received: 18 August 2015 Revised: Online: Published: 01 January 2009
| Citation: |
Liu Nan, Chen Guoping, Hong Zhiliang. A 0.18 μm CMOS fluorescent detector system for bio-sensing application[J]. Journal of Semiconductors, 2009, 30(1): 015002. doi: 10.1088/1674-4926/30/1/015002
****
Liu N, Chen G P, Hong Z L. A 0.18 μm CMOS fluorescent detector system for bio-sensing application[J]. J. Semicond., 2009, 30(1): 015002. doi: 10.1088/1674-4926/30/1/015002.
|
WeChat ID
Journal of Semiconductors © 2017 All Rights Reserved 京ICP备05085259号-2
DownLoad: