J. Semicond. > Volume 37 > Issue 2 > Article Number: 025007

A multi-channel analog IC for in vitro neural recording

Feng Yuan 1, , Zhigong Wang 1, 3, , and Xiaoying Lü 2, 3,

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Abstract: Recent work in the field of neurophysiology has demonstrated that, by observing the firing characteristic of action potentials (AP) and the exchange pattern of signals between neurons, it is possible to reveal the nature of "memory" and "thinking" and help humans to understand how the brain works. To address these needs, we developed a prototype fully integrated circuit (IC) with micro-electrode array (MEA) for neural recording. In this scheme, the microelectrode array is composed by 64 detection electrodes and 2 reference electrodes. The proposed IC consists of 8 recording channels with an area of 5 × 5 mm2. Each channel can operate independently to process the neural signal by amplifying, filtering, etc. The chip is fabricated in 0.5-μ m CMOS technology. The simulated and measured results show the system provides an effective device for recording feeble signal such as neural signals.

Key words: analog integrated circuitsneural signal recordingneural signal amplifiermicro-electrode arrayspseudo resistor

Abstract: Recent work in the field of neurophysiology has demonstrated that, by observing the firing characteristic of action potentials (AP) and the exchange pattern of signals between neurons, it is possible to reveal the nature of "memory" and "thinking" and help humans to understand how the brain works. To address these needs, we developed a prototype fully integrated circuit (IC) with micro-electrode array (MEA) for neural recording. In this scheme, the microelectrode array is composed by 64 detection electrodes and 2 reference electrodes. The proposed IC consists of 8 recording channels with an area of 5 × 5 mm2. Each channel can operate independently to process the neural signal by amplifying, filtering, etc. The chip is fabricated in 0.5-μ m CMOS technology. The simulated and measured results show the system provides an effective device for recording feeble signal such as neural signals.

Key words: analog integrated circuitsneural signal recordingneural signal amplifiermicro-electrode arrayspseudo resistor



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Wattanapanitch R, Sarpeshkar R. A low-power 32-channel digitally programmable neural recording integrated circuit[J]. IEEE Trans Biomed Circuits Syst, 2011, 5(6): 592.

[1]

Kreiman G. Neural coding: computational and biophysical perspectives[J]. Physics of Life Reviews, 2004, 2: 71.

[2]

Kim S, Bhandari R, Klein M. Integrated wireless neural interface based on the Utah electrode array[J]. J Springer Biomed Micro devices, 2009, 11: 453.

[3]

Fraunhofer Electronic Packaging and System Integration (IZM). Http://www[J]. .

[4]

Nordhausen C T, Maynard E M, Normann R A. Single unit recording capabilities of a 100 microelectrode array[J]. Brain Res, 1996, 726: 129.

[5]

Rousche P J, Pellinen D S, Williams J C. Flexible polyimide-based intra-cortical electrode arrays with bio-active capability[J]. IEEE Trans Biomed Eng, 2001, 48(3): 361.

[6]

Thomas C A, Springer P A, Okun L M. Miniature microelectrode array to monitor bioelectric activity of cultured cells[J]. Experimental Cell Research, 1972, 74(1): 61.

[7]

Hoogwerf A C, Wise K D. A three-dimentional microelectrode array for chronic neural recording[J]. IEEE Trans Biomed Eng, 1994, 41(12): 1136.

[8]

Fromherz P. Electrical interfacing of nerve cells and semiconductor chips[J]. Chem Phys Chem, 2002, 3(3): 276.

[9]

Sui Xiaohong, Liu Jinbin, Gu Ming. Simulation of a monolithic integrated CMOS preamplifier for neural recordings[J]. Journal of Semiconductors, 2005, 26(12): 2275.

[10]

Pan H X, Lü X Y, Wang Z G. CMOS Microelectrode array for signal recording and stimulating of neurons assemble[J]. 3rd International Conference on Bioinformatics and Biomedical Engineering, 2009: 1.

[11]

Gui Yun, Zhang Xu, Wang Yuan. A multi-channel fully differential programmable integrated circuit for neural recording application[J]. Journal of Semiconductors, 2013, 34(10): 105009.

[12]

Harrison R R, Charles C. A low-power low-noise CMOS amplifier for neural recording applications[J]. IEEE J Solid-State Circuits, 2003, 38(6): 958.

[13]

Kim J, Chae M S, Liu W. A 220 nW neural amplifier for multi-channel neural recording systems[J]. IEEE International Symposium on Circuits and Systems, 2009: 1257.

[14]

Majidzadeh V, Schmid A, Leblebici Y. Energy efficient low-noise neural recording amplifier with enhanced noise efficiency factor[J]. IEEE Trans Biomed Circuits Syst, 2011, 5(3): 262.

[15]

Wattanapanitch W, Fee M, Sarpeshkar R. An energy-efficient micropower neural recording amplifier[J]. IEEE Trans Biomed Circuits Syst., 2007, 1(2): 136.

[16]

Zhang F, Holleman J, Otis B P. Design of ultra-low power biopotential amplifiers for biosignal acquisition applications[J]. IEEE Trans Biomed Circuits Syst, 2012, 6(4): 344.

[17]

Lopez C M, Andrei A, Mitra S. An implantable 455-active-electrode 52-channel CMOS neural probe[J]. IEEE Int Solid-State Circuits Conf Dig Tech Papers, 2013: 288.

[18]

Muller R, Le H P, Li W. A miniaturized 64-channel, 225 μ W electrocorticographic wireless neural sensor[J]. IEEE Int Solid-State Circuits Conf Dig Tech Papers, 2014: 412.

[19]

Fang T, Lü X, Wang Z. Design of neural stimulation and neural signal detecting circuit for monolithic integrated MEA[J]. International Symposium on Bioelectronics and Bioinformatics (ISBB), 2011: 69.

[20]

Wattanapanitch R, Sarpeshkar R. A low-power 32-channel digitally programmable neural recording integrated circuit[J]. IEEE Trans Biomed Circuits Syst, 2011, 5(6): 592.

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F Yuan, Z G Wang, X Lü. A multi-channel analog IC for in vitro neural recording[J]. J. Semicond., 2016, 37(2): 025007. doi: 10.1088/1674-4926/37/2/025007.

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Manuscript received: 12 May 2015 Manuscript revised: Online: Published: 01 February 2016

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